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Ultrasensitive Test Reveals Corrupted Protein Linked With Alzheimer’s & CTE

Researchers at the National Institutes of Health proclaimed that they have developed a novel ultrasensitive test with an ability to detect a corrupted protein linked with chronic traumatic encephalopathy (CTE) and, Alzheimer’s disease. CTE is a health condition mostly found in military veterans, athletes, and others with a past record of repetitive brain disorders. The latest advanced technique might offer early diagnosis of such conditions and open novel research into how they are invented.

This research is published in the journal Acta Neuropathologica. Scientists explained the process with which they modified a diagnostic test that was initially intended for prion diseases to find out atypical bunches of tau protein. Same as numerous other proteins engaged in neurological diseases, tau protein bunches can offer their contribution significantly into CTE and Alzheimer’s disease processes. The research involved brain specimens from about 16 patients with Alzheimer’s, two boxers suffering from CTE, and various control cases that involved other brain disorders.

On a similar note, finding out an effective technique to identify individuals with a minor cognitive impairment that apparently will lead to Alzheimer’s has eluded researchers for many years. But, recently, the research team headed by David Loewenstein, Ph.D., Director, Center for Cognitive Neuroscience and Aging (CNSA), stated that it has successfully discovered a novel approach that might detect new methods for the same.

The latest study named “Utilizing Semantic Intrusions to Identify Amyloid Positivity in Mild Cognitive Impairment” is supported by the National Institute on Aging. It can be accessed online in the journal Neurology. Together with Rosie E. Curiel, study co-author, and their colleagues, Loewenstein carried out research on almost 88 individuals with amnestic minor cognitive impairment (aMCI). The research noted approximately 34 patients with underlying, prodromal Alzheimer’s. This identification was done based on earlier record and amyloid positive examinations.

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